Real-World Evidence · Clinical Research · Consumer Insights

The Research Partner for Products That Can't Use the Standard Playbook

IRB-approved study design. Publication-ready data. Built for categories where traditional clinical trials and insurance claims data don't reach — tobacco and nicotine, telehealth, compounding pharmacy, behavioral health, and regulated natural products.

18
Peer-reviewed publications
25,000+
Participants in registry
199
Studies conducted
56M+
Real-world data points
The most-published real-world evidence CRO for regulated natural products.
Our Platform

Penzai · The real-world evidence infrastructure behind every MoreBetter study.

We didn't adapt a survey tool. We built Penzai from the ground up for longitudinal real-world evidence — the same participants, day after day, generating the kind of data that snapshot polls and one-time clinical trials can't reach.

Daily, Time-Locked Data Capture
Daily questions delivered on schedule — minimizing recall bias and producing data dense enough to model dose, onset, and response patterns across time.
Multi-Wave Panel Orchestration
Run multi-cohort, multi-wave longitudinal studies on a single platform. Schedule recurring data captures, manage gap periods between waves, and track every participant across the full study lifecycle.
Wearables & Biomarker-Ready
Built to merge self-report data with objective signals from wearables, apps, and biomarker labs. Activate biometric ground truth alongside subjective experience on any study that requires it.
HIPAA-Compliant & Audit-Logged
HIPAA-compliant infrastructure with encrypted data transport, role-based access controls, and complete audit trails on protocol changes, instrument versions, participant data, and exports. Defensible to healthcare buyers, peer-reviewed publication, and regulatory review.
Where We're Going

Empirical AI, ethically built.

Most AI in healthcare predicts outcomes from molecular structure or insurance claims. Ours learns from real human responses — mapped to formulation profile, dose, and individual factors. We're building the empirical AI layer of real-world evidence: a model that gets smarter every quarter as the dataset grows, designed first for the categories that need it most and built to scale across every product category that deserves better data.

Trained on Real Outcomes
AI built from actual human responses — not molecular simulations or claims-data inference. The data the AI learns from determines what the AI can predict.
Compounding by Design
Every new study expands the dataset and sharpens the model. The longer you collect, the more precisely we predict — for your products and the populations that use them.
Ethically Bounded
Participants are de-identified. Formulation is the unit of analysis, not the person. AI-assisted analysis stays within scoped access. Built to earn trust, not exploit it.
Research Programs

What We Build Evidence For

Four research programs, one underlying platform. Whether you're preparing for reimbursement, generating brand-level evidence, sharpening category positioning, or running ongoing consumer pulses — Penzai powers it all.

Program 01

Real-World Evidence for Reimbursement

Generate the data your products will need to qualify for ACO, EOM, and emerging Medicaid frameworks. Our protocols capture the five core data domains — baseline, product exposure, outcomes, safety, and substitution — that reimbursement programs require. Brands collecting now position ahead of the regulatory wave.

Program 02

Longitudinal Evidence Studies

Brand-level longitudinal studies on the Penzai platform. Same participants, daily data, structurally validated outcomes — designed once and used wherever the data needs to go: marketing claims, R&D decisions, peer-reviewed publication, or regulatory submission. From 30-day consumer studies to multi-year IRB-approved clinical research, the same infrastructure powers it all.

Program 03

Competitive Benchmarking

See how your product performs against every major brand in your category. Real-world data on outcomes, repurchase intent, side effects, and consumer preference — measured across the same longitudinal participants, not snapshot polls.

Program 04

Functional Consumer Insights

Six pulse surveys per year to our 25,000+ participant panel. Brands shape the questions; participants deliver structurally validated responses that academic and regulatory audiences trust. Annual subscription.

Proof

Trusted by brands and researchers who need data that holds up.

Participating in this study allows us to stay at the forefront of innovation while helping to shape standards that prioritize safety, quality, and consumer education. We're thrilled to sponsor this study and contribute to groundbreaking research in this rapidly evolving industry.

Justin Tidwell
Justin Tidwell
CEO · Nowadays

We partnered with MoreBetter to gather valuable insights related to product efficacy, published those results, got more traffic to the site, and converted that traffic better than we had been doing without their data. +1 for RWD.

Tony Schwartz
Tony Schwartz
Slumber

MoreBetter's software is intuitive, powerful, and perfectly tailored for anyone looking to track real world data to gain insights into their formulations and products. The ability to customize and monitor individual responses for different treatments has been invaluable.

Andrea Baillo
Andrea Baillo
Researcher
Research Credentials

Where our research lives.

Peer-reviewed publications across leading medical journals, developed in partnership with university research teams since 2018.

Published In
Springer Nature
Elsevier
Scientific Reports
Yale Journal of Biology and Medicine
Frontiers
Karger
Journal of Clinical Gastroenterology
Clinical Therapeutics
MDPI
Academic Partners
University of Michigan
University of Mississippi
University of New Mexico
Hebrew University
Wayne State University
Florida Gulf Coast University
How It Works

From protocol to publishable evidence, in four steps.

Step 01
Design the Protocol
We scope the right study with you — structured for IRB review when needed and built for the data's end-use: marketing claims, regulatory submission, or peer-reviewed publication.
Step 02
Recruit Participants
We handle end-to-end participant recruitment — via our 25,000+ registry, partner registries, targeted paid acquisition channels, or your own customer list. Penzai manages enrollment, consent, and onboarding across every source.
Step 03
Capture Data Daily
Participants respond to scheduled prompts via Penzai — daily for most studies, or at any cadence the protocol requires. We monitor compliance, manage incentives, and ensure data quality across the full study lifecycle.
Step 04
Deliver Evidence
Statistical analysis, audit-ready exports, and a results report you can use in marketing, R&D decisions, regulatory submissions, or peer-reviewed publication.
Get Started

Ready to generate evidence that holds up?

Start the conversation and we'll scope a study built for the data your business actually needs — whether that's marketing claims, regulatory submission, or peer-reviewed publication.

Request a Research Consultation